Paracrine calcitonin in prostate cancer is linked to CD44 variant expression and invasion.

Abstract

BACKGROUND Calcitonin (CT) exerts an autocrine/paracrine influence on prostatic tumor invasion through coupling to transduction protein Gsalpha. Cell adhesion glycoprotein CD44 variant v7-v10 also faciliates invasion, but its modulation by the CT-Gsalpha system was unexplored. MATERIALS AND METHODS LnCaP, PC-3 and metastasis-derived PC-3M cell lines were… (More)

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