Paracrine apoptotic effect of p53 mediated by tumor suppressor Par-4.

Abstract

The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This… (More)
DOI: 10.1016/j.celrep.2013.12.020

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