Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system.

@article{Ogunshola2002ParacrineAA,
  title={Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system.},
  author={Omolara O. Ogunshola and Anica Antic and Maria J Donoghue and S K Fan and Hyun Hae Kim and William B. Stewart and Joseph A. Madri and Laura R. Ment},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 13},
  pages={11410-5}
}
Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within the developing cerebral cortex. Here we investigate the characteristics of VEGF expression by neurons and test the hypothesis that VEGF may serve both paracrine and autocrine functions in the developing central nervous system. To begin to address these questions, we assayed expression of VEGF and one of its potential receptors, Flk-1 (VEGFR-2), in… CONTINUE READING

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