Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells

  title={Paracrine Regulation of Thyroid-Hormone Synthesis by C Cells},
  author={Jos{\'e} Mar{\'i}a Fern{\'a}ndez-Santos and Jes{\'u}s Morillo-Bernal and Roc{\'i}o Garc{\'i}a-Mar{\'i}n and Jos{\'e} Carmelo Utrilla and In{\'e}s Mart{\'i}n-Lacave},
Thyroid hormone secretion by follicular cells is mainly regulated by thyroid-stimulating hormone (TSH) from the pituitary gland, which in turn is controlled by thyrotropin releasing hormone (TRH) of hypothalamic origin. However, there are a number of additional endocrine mediators, such as estrogens and corticosteroids, which are also involved in the regulation of the biosynthesis of T3 and T4. Besides this extrathyroidal main regulation, thyroid function and growth are under the influence of… CONTINUE READING


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