Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli.

Abstract

Kidney glomerulus mesangial cells fail to develop in mice carrying targeted null mutations in the platelet-derived growth factor (PDGF)-B or PDGF-Rbeta genes. We have examined the pattern of expression of these genes and smooth muscle markers during kidney development, to address the possible mechanisms underlying the mutant phenotypes. In wild-type embryos… (More)

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@article{Lindahl1998ParacrinePS, title={Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli.}, author={Per Lindahl and Mikael Hellstr{\"{o}m and Mattias Kal{\'e}n and L. S. Karlsson and Milos Pekny and Marcela Pekna and Philippe Soriano and Christer Betsholtz}, journal={Development}, year={1998}, volume={125 17}, pages={3313-22} }