Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine


The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The HIFα subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. We confirmed that TNBC cells secrete glutamate, which we found is both… (More)
DOI: 10.1016/j.cell.2016.05.042


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