Paracoccidioides brasiliensis expresses both glycosylphosphatidylinositol-anchored proteins and a potent phospholipase C.

@article{Heise1995ParacoccidioidesBE,
  title={Paracoccidioides brasiliensis expresses both glycosylphosphatidylinositol-anchored proteins and a potent phospholipase C.},
  author={Norton Heise and Luiz R Travassos and Maria Christina Lins de Almeida},
  journal={Experimental mycology},
  year={1995},
  volume={19 2},
  pages={111-9}
}
This study reports, for the first time, the detection of glycosylphosphatidylinositol (GPI) membrane anchors in proteins of a pathogenic fungus, Paracoccidioides brasiliensis. Taking into account that fungal antigens are found in the sera of paracoccidioidiomycosis patients and that cleavage of this glycolipid by phospholipases is a means of selective protein release, the presence of an enzyme with this property has also been investigated. Using a methodological approach in which the proteins… CONTINUE READING