Paracoagulation of fibrinogen in vitro and in vivo by protein T of Steptococcus pyogenes.

@article{Ludwicka1978ParacoagulationOF,
  title={Paracoagulation of fibrinogen in vitro and in vivo by protein T of Steptococcus pyogenes.},
  author={A Ludwicka and Janusz Jeljaszewicz},
  journal={Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie},
  year={1978},
  volume={241 3},
  pages={301-7}
}
Protein T was isolated from type 12 Streptococcus pyogenes cell wall by digestion with CNBr-sepharose linked trypsin and purified by ion exchange chromatography on QAE Sephadex A-50. Homogenous and not contaminated with other streptococcal proteins, antigen T, possesses paracoagulating activities similar to the effect of protamine sulphate. Protein T, applied intravenously to mice, accumulated mainly in kidneys and resulted in deposition of fibrinogen and its derivatives.