Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta‐analysis

@article{Eyers2011ParacetamolIP,
  title={Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta‐analysis},
  author={Sally Eyers and Mark W Weatherall and Sarah Jefferies and Richard Beasley},
  journal={Clinical \& Experimental Allergy},
  year={2011},
  volume={41}
}
Cite this as: S. Eyers, M. Weatherall, S. Jefferies and R. Beasley, Clinical & Experimental Allergy, 2011 (41) 482–489. 
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Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.
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References

SHOWING 1-10 OF 35 REFERENCES
Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood
  • S. ShaheenR. Newson D. Strachan
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2005
TLDR
This data indicates that use of paracetamol in late pregnancy is associated with an increased risk of early wheezing in the offspring and this work aims to establish a causative mechanism behind this association.
Is the Effect of Prenatal Paracetamol Exposure on Wheezing in Preschool Children Modified by Asthma in the Mother?
TLDR
The frequent usage of paracetamol during pregnancy is associated with the prevalence of wheezing in offspring during preschool years, and asthma in the mother might modify this association.
Acetaminophen use and risk of asthma, rhinoconjunctivitis and eczema in adolescents : ISAAC Phase Three
Summary: This global study has shown that the reported use of acetaminophen is associated with an exposure-dependent increased risk of the symptoms of asthma, rhinoconjunctivitis and eczema in
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.
  • V. PerskyJ. Piorkowski A. Busso
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2008
Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis.
TLDR
The results of this review are consistent with an increase in the risk of asthma and wheezing in both children and adults exposed to acetaminophen.
Intake of Paracetamol and Risk of Asthma in Adults
TLDR
There was a higher prevalence of new-onset asthma in subjects who reported frequent intake of paracetamol at baseline compared with subjects without this determinant, and the result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema, and intake of medications other than par acetamol.
The role of paracetamol in the pathogenesis of asthma
  • H. FarquharA. Stewart R. Beasley
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2010
TLDR
Further research is urgently required, in particular randomized‐controlled trials (RCTs) into the long‐term effects of frequent paracetamol use in childhood, to determine the magnitude and characteristics of any such risk.
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