Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta‐analysis

  title={Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta‐analysis},
  author={Sally Eyers and Mark W Weatherall and Sarah Jefferies and Richard Beasley},
  journal={Clinical \& Experimental Allergy},
Cite this as: S. Eyers, M. Weatherall, S. Jefferies and R. Beasley, Clinical & Experimental Allergy, 2011 (41) 482–489. 
Paracetamol exposure and asthma: What does the evidence say? An overview of systematic reviews
To conduct an umbrella review collating the existing evidence to determine whether there is an association between exposure of Paracetamol in‐utero or in infancy and the development of childhood
Randomized controlled trial of asthma risk with paracetamol use in infancy – a feasibility study
  • J. RileyI. Braithwaite R. Beasley
  • Medicine, Psychology
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2015
There is non‐experimental evidence that paracetamol (acetaminophen) use may increase the risk of developing asthma. However, numerous methodological issues need to be resolved before undertaking a
The association between paracetamol and asthma is still under debate
There are many arguments that suggest a relationship between the use of paracetamol with the appearance of asthmatic symptoms, however the evidence is inconclusive.
Over-the-counter medications and pregnancy: an integrative review.
Many over-the-counter medications are available to help alleviate common discomforts experienced during pregnancy, but healthcare providers must familiarize themselves with these medications.
Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study
A robust association was found between prenatal exposure to maternal use of prescription paracetamol and the risk of asthma; however, noncausal explanations could not be ruled out for such association.
Association of maternal prenatal acetaminophen use with the risk of attention deficit/hyperactivity disorder in offspring: A meta-analysis
The timing and duration of acetaminophen use during pregnancy may have a major effect on the risk of attention deficit/hyperactivity disorder in offspring.
Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California
Black/African American and Asian/Pacific Islander children showed a greater than two-fold risk for asthma diagnosis and wheezing associated with the exposure, and high maternal psychosocial stress also modified the exposure-outcome relationships.
Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes.
This study, which is population-based and the largest of its kind, did not find support for general early life infections, infection frequency or use of antibiotics or acetaminophen to play a major role in childhood T1D.
Intrauterine Exposure to Acetaminophen and Adverse Developmental Outcomes: Epidemiological Findings and Methodological Issues.
Given the high prevalence of use, findings regarding intrauterine exposure to acetaminophen on multiple child health outcomes raise concerns and research on causal and non-causal mechanisms that might explain these associations should be a priority.


Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood
  • S. ShaheenR. Newson D. Strachan
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2005
This data indicates that use of paracetamol in late pregnancy is associated with an increased risk of early wheezing in the offspring and this work aims to establish a causative mechanism behind this association.
Is the Effect of Prenatal Paracetamol Exposure on Wheezing in Preschool Children Modified by Asthma in the Mother?
The frequent usage of paracetamol during pregnancy is associated with the prevalence of wheezing in offspring during preschool years, and asthma in the mother might modify this association.
Acetaminophen use and risk of asthma, rhinoconjunctivitis and eczema in adolescents : ISAAC Phase Three
Summary: This global study has shown that the reported use of acetaminophen is associated with an exposure-dependent increased risk of the symptoms of asthma, rhinoconjunctivitis and eczema in
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.
  • V. PerskyJ. Piorkowski A. Busso
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2008
Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis.
The results of this review are consistent with an increase in the risk of asthma and wheezing in both children and adults exposed to acetaminophen.
Intake of Paracetamol and Risk of Asthma in Adults
There was a higher prevalence of new-onset asthma in subjects who reported frequent intake of paracetamol at baseline compared with subjects without this determinant, and the result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema, and intake of medications other than par acetamol.
The role of paracetamol in the pathogenesis of asthma
  • H. FarquharA. Stewart R. Beasley
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2010
Further research is urgently required, in particular randomized‐controlled trials (RCTs) into the long‐term effects of frequent paracetamol use in childhood, to determine the magnitude and characteristics of any such risk.