Paracetamol in fever in critically ill patients—an update☆,☆☆

@article{Chiumello2017ParacetamolIF,
  title={Paracetamol in fever in critically ill patients—an update☆,☆☆},
  author={Davide Alberto Chiumello and Miriam Gotti and Giordano Luca Vergani},
  journal={Journal of Critical Care},
  year={2017},
  volume={38},
  pages={245–252}
}
&NA; Fever, which is arbitrary defined as an increase in body temperature above 38.3°C, can affect up to 90% of patients admitted in intensive care unit. Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor &agr;, interleukin 1, interleukin 6, and interferons). Fever is associated with increased length of stay in intensive care unit and with a worse outcome in some subgroups of patients (mainly neurocritically ill patients). Although fever can increase… 
The Effect of Acetaminophen on Temperature in Critically Ill Children: A Retrospective Analysis of Over 50,000 Doses
  • S. Ray, L. Rogers, K. Brown, M. Peters
  • Medicine
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2018
TLDR
Acetaminophen is associated with a significant decrease in temperature in children with fever, however, temperature may decrease following fever without acetaminophen in the PICU, and the threshold to use acetamophen must be understood to determine the true effect on temperature in any future trials.
Fever suppression in patients with infection: State of the evidence
TLDR
Fever management interventions are commonly administered to patients with infection and sepsis by ICU clinicians, and recent evidence related to the impact of fever suppression interventions warrants review by critical care nurses.
Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study
TLDR
Practice preferences vary substantially regarding general supportive and preventive measures in TBI patients at ICUs of European neurotrauma centers, which provides an opportunity for future comparative effectiveness research.
Evidence-based out-of-hours hospital medicine
TLDR
In this narrative review, five common situations peculiar to the OOH general ward setting are discussed with reference to potential areas of inefficiency and unnecessary management steps.
Optimizing sepsis care: from early recognition to life after sepsis
TLDR
It is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights and may download and print one copy of any publication from the public portal for the purpose of private study or research.
Effect of selective brain cooling versus core cooling on achieving target temperature among patients with severe traumatic brain injury
TLDR
The selective brain cooling method is effective in achieving target temperature than the core cooling method and shows early improvement in neurological injury severities than those subjected to the corecooling method.
Mechanism of insulin resistance in obesity: a role of ATP
TLDR
ATP may represent the primary signal of insulin resistance in the cellular protective response to the substrate oversupply, and the prevention of ATP overproduction represents a key strategy for insulin sensitization.
1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study.
TLDR
The design and synthesis of a new series of 1,4-dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents and COX-1/2 inhibitors and the predicted in silico studies of all the compounds support their potential as drug candidates.
Host-guest paracetamol/cyclodextrin complex formation evaluated from coupled diffusion measurements
Abstract Ternary mutual diffusion coefficients (D11, D22, D12 and D21) measured by the Taylor dispersion method are reported for aqueous solutions of paracetamol (1) in the presence of β-cyclodextrin
Coupled mutual diffusion in aqueous paracetamol + sodium hydroxide solutions
Abstract Ternary mutual diffusion coefficients (Dik) measured by the Taylor dispersion method are reported for aqueous paracetamol + NaOH solutions at 25.00 °C and concentrations up to 0.050 mol
...
1
2
...

References

SHOWING 1-10 OF 47 REFERENCES
Acetaminophen has limited antipyretic activity in critically ill patients.
TLDR
Acetaminophen has significant albeit modest antipyretic activity in critically ill patients and is effective in this population of patients with systemic inflammatory response syndrome.
Clinical review: Fever in intensive care unit patients
TLDR
The anti-inflammatory effects of HSPs, coupled with improved survival of animal models with fever and infection, call into question the routine practice of treating fever in critically ill patients.
Fever effects and treatment in critical care: literature review.
TLDR
Significant implications for antipyretic treatment of critically ill adults are provided and areas for future research are suggested, including fever suppression and return to normothermia improved outcomes of septic shock patients.
Randomized trial of the effect of intravenous paracetamol on inflammatory biomarkers and outcome in febrile critically ill adults
TLDR
The results suggest that antipyretic therapy may not be indicated in all ICU patients and allowing fever to take its natural course does not appear to have detrimental effects on critically ill patients with SIRS and may avoid unnecessary expenses.
The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study.
TLDR
Aggressively treating fever in critically ill patients may lead to a higher mortality rate, and the study was stopped after the first interim analysis due to the mortality difference.
Occurrence and outcome of fever in critically ill adults*
TLDR
Fever is common in patients admitted to theICU and its occurrence and impact on outcome varies among defined patient populations, and the influence of fever on the ICU mortality varied significantly according to its timing of onset, degree, and main admission category.
Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study
TLDR
It is found that treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen independently increased 28-day mortality for septic patients and in non-septic patients, high fever (≥ 39.5°C) independently associated with mortality, without association of administration of NSAIDs or acetamination with mortality.
Early antipyretic exposure does not increase mortality in patients with gram-negative severe sepsis: a retrospective cohort study
TLDR
Early antipyretic therapy is not associated with increased mortality in febrile patients with gram-negative bacteremia hospitalized with severe sepsis or septic shock, and this study was a single-center retrospective cohort study.
Fever in subarachnoid hemorrhage
TLDR
Fever in SAH is associated with vasospasm and poor outcome independently of hemorrhage severity or presence of infection, and three variables independently predicted fever occurrence.
Antipyretic therapy in febrile critically ill adults: A systematic review and meta-analysis.
TLDR
No evidence that fever treatment influences mortality in critically ill adults without acute neurological injury is found, however, studies were underpowered to detect clinically important differences.
...
1
2
3
4
5
...