Paracetamol for pain in adults

  title={Paracetamol for pain in adults},
  author={Bruno Tirotti Saragiotto and Christina Abdel Shaheed and Christopher G. Maher},
### What you need to know A 65 year old retired engineer has experienced a flare up in the pain he experiences with his osteoarthritic knee. While seeing his general practitioner (GP) about a skin lesion, he mentions the knee problem and asks if he should use paracetamol to manage the pain. The patient is overweight and physically inactive. Paracetamol (acetaminophen) is one of the most widely used over-the-counter drugs around the world for the treatment of pain.1 More than 100 different… 

Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis

A number of non-pharmaceutical alternatives (bioactive nutraceuticals) have been developed that may reduce NSAID and analgesia use while maintaining pain reduction and improvements in physical function.

Intravenous Acetaminophen Does Not Provide Adequate Postoperative Analgesia in Dogs Following Ovariohysterectomy

Following ovariohysterectomy in dogs, there was no detectable analgesic effect of a 20 mg/kg dosage of intravenous acetaminophen administered at the end of surgery.

Cardiovascular effects and safety of (non-aspirin) NSAIDs

The authors assess the cardiovascular safety of NSAIDs and present an approach for their use in the holistic management of pain, as non-pharmacological measures (physiotherapy, exercise and weight management) are feasible options for many patients to achieve pain control while minimizing pharmacological analgesic needs, with additional benefits in terms of cardiovascular risk management and wellbeing.

Drugs for chronic pain.

In August 2020, the National Institute for Health and Care Excellence (NICE) published the draft guidance on chronic pain, which perhaps controversially advises against the use of all drugs except

Paracetamol as organic compound induced the decrease in the antioxidant enzymes and thiobarbituric acid-reactive substances in male rabbits Universal Paracetamol as organic compound induced the decrease in the antioxidant enzymes and thiobarbituric acid-reactive substances in male rabbits

Results obtained showed that paracetamol significantly induced thiobarbituric acid-reactive substances [TBARS; the marker of lipid peroxidation] in plasma, while the activities of glutathione S-transferase [GST], superoxide dismutase [SOD] and catalase [CAT], and the level of sulfhydryl groups [SH-group] were decreased in blood plasma.

National Poison Center Calls Before vs After Availability of High-Dose Acetaminophen (Paracetamol) Tablets in Switzerland

The results of this study support the need for public health measures to restrict the availability of the 1000-mg acetaminophen tablet to minimize the potential for accidentalacetaminophen-related harm.

A DFT study of the interaction of aspirin, paracetamol and caffeine with one water molecule

We have studied the interaction of water with three important analgesics, aspirin, paracetamol and caffeine using DFT calculations and FTIR-ATR spectroscopy. In our study, water is used as a probe

Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form

: A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and



Paracetamol for low back pain.

It is found that paracetamol does not produce better outcomes than placebo for people with acute LBP, and it is uncertain if it has any effect on chronic LBP.

Paracetamol versus placebo for knee and hip osteoarthritis.

At 3 weeks' to 3 months' follow-up, there was high-quality evidence that paracetamol provided no clinically important improvements in pain and physical function, and there was less certainty around the risk of serious adverse events, withdrawals due to adverse events and the rate of abnormal liver function tests, due to wide CIs or small event rates.

What dose of paracetamol for older people?

  • Medicine
    Drug and Therapeutics Bulletin
  • 2018
The use of paracetamol is reviewed, its pharmacokinetics, the mechanisms by which it can cause liver damage and whether frail older people are at greater risk of adverse effects are considered.

Efficacy of commonly prescribed analgesics in the management of osteoarthritis: a systematic review and meta-analysis

The effects of 5 major drug categories in the treatment of OA pain were reviewed with data extracted from 29 studies published from 2006 to 2016 and acetaminophen was found to have an RC value close to that of oral NSAIDs.

Paracetamol: mechanism of action, applications and safety concern.

This work, in conjunction with the latest reports on the mechanism of action of paracetamol, tries to point out that it is not a panacea devoid of side effects, and indeed, especially when is taken regularly and in large doses, there is a risk of serious side effects.

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults.

Paracetamol 1000 mg alone is statistically superior to placebo in the treatment of acute migraine, but the NNT of 12 for pain-free response at two hours is inferior to at of other commonly used analgesics.

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth.

Ibuprofen was found to be a superior analgesic to paracetamol at several doses with high quality evidence suggesting that ib uprofen 400 mg is superior to 1000 mg paracetmol based on pain relief and the use of rescue medication meta-analyses.

Acetaminophen safety and hepatotoxicity – where do we go from here?

The mechanism and metabolism of acetaminophen and the features of toxicity in adults, pediatric and special populations are reviewed and expert opinion is presented herein to aid in reducing the frequency and severity of liver injury fromacetaminophen.

Frequency of analgesic use and risk of hypertension in younger women.

Use of NSAIDs and use of acetaminophen were significantly associated with increased risk of hypertension, but aspirin use was not.

Pharmacologic therapy for acute pain.

There is little evidence that one opioid is superior for pain control, but there are some pharmacologic differences among opioids.