Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis

  title={Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis},
  author={Meetwell Cheelo and Caroline J. Lodge and S. Dharmage and Julie Anne Simpson and Melanie C Matheson and Joachim Heinrich and Adrian J. Lowe},
  journal={Archives of Disease in Childhood},
  pages={81 - 89}
Background and objective While paracetamol exposure in pregnancy and early infancy has been associated with asthma, it remains unclear whether this is confounded by respiratory tract infections, which have been suggested as an alternative explanation. We undertook a systematic review and meta-analysis of longitudinal studies that reported the association between paracetamol exposure during pregnancy or infancy and the subsequent development of childhood asthma (≥5 years). Methods Two… 
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There are many arguments that suggest a relationship between the use of paracetamol with the appearance of asthmatic symptoms, however the evidence is inconclusive.
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Given the high prevalence of use, findings regarding intrauterine exposure to acetaminophen on multiple child health outcomes raise concerns and research on causal and non-causal mechanisms that might explain these associations should be a priority.
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  • 2016
Whatever empirical data exist do not support the suggestion that the use of acetaminophen during pregnancy increases the risk of autism in the offspring, and this new finding suggests that the predisposition is toward the hyperkinetic syndrome rather than to autism.
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Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort.
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Prenatal paracetamol exposure and asthma: further evidence against confounding.
The findings suggest that the relation between maternal use of paracetamol in pregnancy and childhood asthma is unlikely to be confounded by unmeasured behavioural factors linked to par acetamol use.
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The results of this review are consistent with an increase in the risk of asthma and wheezing in both children and adults exposed to acetaminophen.
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The results suggest that acetaminophen use during pregnancy does not increase risk of asthma in children, and use during both the first and the third trimester was associated with a significantly reduced risk.
Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study.
Paracetamol use during pregnancy was associated with an increased risk of asthma and wheezing in childhood, and if this association is causal, the clinical practice on use of par acetamol during pregnancy may need to be revisited.
Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study
A robust association was found between prenatal exposure to maternal use of prescription paracetamol and the risk of asthma; however, noncausal explanations could not be ruled out for such association.
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  • 2008
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