Paracetamol and cyclooxygenase inhibition: is there a cause for concern?

@article{Hinz2012ParacetamolAC,
  title={Paracetamol and cyclooxygenase inhibition: is there a cause for concern?},
  author={Burkhard Hinz and Kay Brune},
  journal={Annals of the rheumatic diseases},
  year={2012},
  volume={71 1},
  pages={
          20-5
        }
}
Paracetamol is recommended as first-line therapy for pain associated with osteoarthrosis and is one of the most widely used over-the-counter analgesic drugs worldwide. Despite its extensive use, its mode of action is still unclear. Although it is commonly stated that paracetamol acts centrally, recent data imply an inhibitory effect on the activity of peripheral prostaglandin-synthesising cyclooxygenase enzymes. In this context paracetamol has been suggested to inhibit both isoforms in tissues… CONTINUE READING
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