Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.

@article{Pei2016ParacellularES,
  title={Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.},
  author={Lei Pei and Glenn Solis and Mien T X Nguyen and Nikhil Kamat and Lynn K Magenheimer and Min Zhuo and Jiahua Li and Joshua N Curry and Alicia A McDonough and Timothy A. Fields and William J. Welch and Alan S L Yu},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 7},
  pages={
          2509-18
        }
}
Efficient oxygen utilization in the kidney may be supported by paracellular epithelial transport, a form of passive diffusion that is driven by preexisting transepithelial electrochemical gradients. Claudins are tight-junction transmembrane proteins that act as paracellular ion channels in epithelial cells. In the proximal tubule (PT) of the kidney, claudin-2 mediates paracellular sodium reabsorption. Here, we used murine models to investigate the role of claudin-2 in maintaining energy… CONTINUE READING
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