Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.

  title={Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination.},
  author={Conor Mc Guire and Peter Wieghofer and Lynn Elton and David Muylaert and Marco Prinz and Rudi Beyaert and Geert van Loo},
  journal={Journal of immunology},
  volume={190 6},
The paracaspase MALT 1 is a major player in lymphocyte activation and proliferation. MALT1 mediates Ag-induced signaling to the transcription factor NF-κB by functioning both as a scaffold protein and cysteine protease. We studied the role of MALT1 in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. MALT1-knockout mice did not develop any clinical symptoms of EAE. In addition, lymphocyte and macrophage infiltration into the spinal cord… CONTINUE READING


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