Parabrachial–lateral pontine neurons link nociception and breathing

  title={Parabrachial–lateral pontine neurons link nociception and breathing},
  author={M C Jiang and George F. Alheid and Tara Calandriello and Donald R. McCrimmon},
  journal={Respiratory Physiology & Neurobiology},
We investigated the role of the parabrachial complex in cutaneous nociceptor-induced respiratory stimulation in chloralose-urethane anesthetized, vagotomized rats. Noxious stimulation (mustard oil, MO) applied topically to a forelimb or hindlimb enhanced the peak amplitude of the integrated phrenic nerve discharge and, with forelimb application, increased phrenic nerve burst frequency. Bilateral inactivation of neural activity in the parabrachial complex with injection of the GABA agonist… CONTINUE READING
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