Paraben preservatives but not succinylcholine are cerebral vasodilators in vitro.

@article{Hamilton1990ParabenPB,
  title={Paraben preservatives but not succinylcholine are cerebral vasodilators in vitro.},
  author={J. Hamilton and Y. Zhou and A. Gelb},
  journal={Anesthesiology},
  year={1990},
  volume={73 6},
  pages={
          1252-7
        }
}
  • J. Hamilton, Y. Zhou, A. Gelb
  • Published 1990
  • Medicine
  • Anesthesiology
  • Since the increase in intracranial pressure produced by succinylcholine is temporally associated with intravenous administration, we investigated in vitro a possible direct cerebrovascular effect of this nicotinic drug. Isometric responses were recorded from dog and guinea pig basilar artery rings suspended in modified Krebs' solution at 37 degrees C. After precontracting with a voltage (KCl)- or a receptor (5-hydroxytryptamine)-mediated agonist, cumulative concentration-relaxation curves were… CONTINUE READING
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