Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes

@article{Yanai2004ParapositionDO,
  title={Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes},
  author={Koji Yanai and Naomi Sumida and Kaoru Okakura and Tatsuki Moriya and Manabu Watanabe and Takeshi Murakami},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={848-855}
}
PF1022A, a cyclooctadepsipeptide possessing strong anthelmintic properties and produced by the filamentous fungus Rosellinia sp. PF1022, consists of four alternating residues of N-methyl-L-leucine and four residues of D-lactate or D-phenyllactate. PF1022A derivatives obtained through modification of their benzene ring at the para-position with nitro or amino groups act as valuable starting materials for the synthesis of compounds with improved anthelmintic activities. Here we describe the… CONTINUE READING

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