Para-chlorophenylalanine, serotonin and killing behavior.

  title={Para-chlorophenylalanine, serotonin and killing behavior.},
  author={Klaus A Miczek and Jack L. Altman and James B. Appel and William O. Boggan},
  journal={Pharmacology, biochemistry, and behavior},
  volume={3 3},
Both p-chlorophenylalanine (PCPA) and PCPA methyl ester were found to reliably induce mouse-killing in non-killer rats only when unusually large doses were used (three successive daily injections of 300 mg/kg) and brain serotonin (5-HT) concentration was drastically reduced (about 90 percent). Neither three doses of 100 mg/kg of PCPA nor p-chloroamphetamine (3 times 3.5 mg/kg) caused similar effects in spite of the fact that these compounds depleted brain 5-HT by 85 percent and 60 percent… CONTINUE READING