Para- and Ortho-Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity

@inproceedings{Kim2011ParaAO,
  title={Para- and Ortho-Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity},
  author={Kyung Ho Kim and Diptiman D. Bose and Atefeh Ghogha and Joyce Riehl and Rui Zhang and Christopher D. Barnhart and Pamela J Lein and Isaac N Pessah},
  booktitle={Environmental health perspectives},
  year={2011}
}
BACKGROUND Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined. OBJECTIVE We aimed to define the structure-activity relationship (SAR) for PBDEs and their metabolites toward ryanodine receptors type 1 (RyR1) and type 2 (RyR2) and to determine whether it predicts neurotoxicity. METHODS We analyzed [3H… CONTINUE READING
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