Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.

@article{Chakraborty2013ParaaminosalicylicAA,
  title={Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.},
  author={Sumit Chakraborty and Todd D. Gruber and Clifton E Barry and Helena I M Boshoff and Kyu Y. Rhee},
  journal={Science},
  year={2013},
  volume={339 6115},
  pages={88-91}
}
Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basis of target-based drug discovery. Fifty years later, PAS continues to be used to treat tuberculosis. PAS is assumed to inhibit dihydropteroate synthase (DHPS) in Mycobacterium tuberculosis by mimicking the substrate p-aminobenzoate (PABA). However, we found that sulfonamide inhibitors of DHPS inhibited… CONTINUE READING
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The Chemistry and Chemotherapy of Tuberculosis

  • E. R. Long
  • 1958

We thank C

  • M. J. Brauer et al., Proc. Natl. Acad. Sci. U.S.A. 103, 19302 . Acknowledgments
  • Nathan for critical discussions and reading of…

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