Para-Amino Benzoic Acid as a Bacterial Growth Factor

@article{Rubbo1940ParaAminoBA,
  title={Para-Amino Benzoic Acid as a Bacterial Growth Factor},
  author={S. Rubbo and J. Gillespie},
  journal={Nature},
  year={1940},
  volume={146},
  pages={838-838}
}
THE mode of action of sulphanilamide has been the subject of much recent work. Possibly the most precise contribution has been Woods's discovery of the anti-sulphanilamide effect of p-amino benzoic acid (‘p.a.b.’). In a discussion of this work, Fildes1 has suggested that ‘p.a.b.’ might be considered an essential metabolite for bacteria. It is now inferred that sulphanilamide inactivates an essential coenzymic grouping of the susceptible organism1,2, and in view of Woods's work, this grouping is… Expand
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  • M. G. Sevag, Morris N. Green
  • Biology, Medicine
  • Journal of bacteriology
  • 1944
Woods (1940) reported that 1.2 to 5.8 X 10-8 M of p-aminobenzoic acid (PABA) added to the medium counteracted the complete inhibition of growth (5-day period) of Streptococcus pyogenes (S.Expand
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References

SHOWING 1-4 OF 4 REFERENCES
Nutrient Requirements of Butyric Acid-Butyl Alcohol Bacteria
TLDR
The present investigation is a continuation of studies using butyric-acid butyl-alcohol bacteria, and preliminary results have shown, in media containing ammonium sulfate, glucose and Speakman's salt, that an ether extract of yeast extract is essential for growth of thebutyl- alcohol bacteria. Expand