ParA-mediated plasmid partition driven by protein pattern self-organization.

  title={ParA-mediated plasmid partition driven by protein pattern self-organization.},
  author={Ling Chin Hwang and Anthony Vecchiarelli and Yong-Woon Han and Michiyo Mizuuchi and Yoshie Harada and Barbara E. Funnell and Kiyoshi Mizuuchi},
  journal={The EMBO journal},
  volume={32 9},
DNA segregation ensures the stable inheritance of genetic material prior to cell division. Many bacterial chromosomes and low-copy plasmids, such as the plasmids P1 and F, employ a three-component system to partition replicated genomes: a partition site on the DNA target, typically called parS, a partition site binding protein, typically called ParB, and a Walker-type ATPase, typically called ParA, which also binds non-specific DNA. In vivo, the ParA family of ATPases forms dynamic patterns… CONTINUE READING
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