Par3 and Dynein Associate to Regulate Local Microtubule Dynamics and Centrosome Orientation during Migration

@article{Schmoranzer2009Par3AD,
  title={Par3 and Dynein Associate to Regulate Local Microtubule Dynamics and Centrosome Orientation during Migration},
  author={Jan Schmoranzer and James P Fawcett and Miriam S{\'a}nchez Segura and Serena Carolyn Tan and Richard B Vallee and Tony Pawson and Gregg G. Gundersen},
  journal={Current Biology},
  year={2009},
  volume={19},
  pages={1065-1074}
}
BACKGROUND Centrosome orientation toward the leading edge of migrating cells depends on dynein and microtubules (MTs), as well as a number of signaling factors at the leading edge. However, centrosomes are maintained at the cell center during orientation in fibroblasts, suggesting that factors working at sites other than the leading edge may also be involved. RESULTS In a search for factors that function with dynein in centrosome orientation, we found that the polarity protein Par3 associated… CONTINUE READING
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