Par3 Controls Epithelial Spindle Orientation by aPKC-Mediated Phosphorylation of Apical Pins

@article{Hao2010Par3CE,
  title={Par3 Controls Epithelial Spindle Orientation by aPKC-Mediated Phosphorylation of Apical Pins},
  author={Yi Hao and Quansheng Du and Xinyu Chen and Zhen Zheng and Jeremy L Balsbaugh and Sushmit Maitra and Jeffrey Shabanowitz and Donald F. Hunt and Ian G. Macara},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={1809-1818}
}
BACKGROUND Formation of epithelial sheets requires that cell division occurs in the plane of the sheet. During mitosis, spindle poles align so the astral microtubules contact the lateral cortex. Confinement of the mammalian Pins protein to the lateral cortex is essential for this process. Defects in signaling through Cdc42 and atypical protein kinase C (aPKC) also cause spindle misorientation. When epithelial cysts are grown in 3D cultures, misorientation creates multiple lumens. RESULTS We… CONTINUE READING
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