Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

@article{Guo1998Par4IA,
  title={Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease},
  author={Qing Guo and Weiming Fu and Jun Xie and Hong Luo and Stephen F. Sells and James W. Geddes and Vimala Bondada and Vivek M. Rangnekar and Mark P. Mattson},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={957-962}
}
Prostate apoptosis response-4 (Par-4) is a protein containing both a leucine zipper and a death domain that was isolated by differential screening for genes upreguiated in prostate cancer cells undergoing apoptosis1,2. Par-4 is expressed in the nervous system3, where its function is unknown. In Alzheimer disease (AD), neurons may die by apoptosis, and amyloid β-protein (Aβ) may play a role in this4–11. We report here that Par-4 expression is increased in vulnerable neurons in AD brain and is… CONTINUE READING

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