Par-4: a common facilitator/enhancer of extrinsic and intrinsic pathways of apoptosis.

@article{Mundle2006Par4AC,
  title={Par-4: a common facilitator/enhancer of extrinsic and intrinsic pathways of apoptosis.},
  author={Suneel D Mundle},
  journal={Leukemia research},
  year={2006},
  volume={30 5},
  pages={515-7}
}
Par-4 overexpression has been shown by Boehrer et al. to augment the apoptotic death of Jurkat T cells induced by TNF related Apoptosis Inducing Ligand (TRAIL). Previously, the same authors have demonstrated a parallel augmentation of chemotherapeutic drug-induced apoptosis in the same cell line overexpressing Par-4. Through these and other studies, Par-4 appears to emerge as a general intracellular facilitator of both extrinsic and intrinsic pathways of apoptosis. The ability of Par-4 to… CONTINUE READING

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