Par-1 Controls Myosin-II Activity through Myosin Phosphatase to Regulate Border Cell Migration

@article{Majumder2012Par1CM,
  title={Par-1 Controls Myosin-II Activity through Myosin Phosphatase to Regulate Border Cell Migration},
  author={Pralay Majumder and George Aranjuez and Joseph Amick and Jocelyn A. McDonald},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={363-372}
}
BACKGROUND Localized actomyosin contraction couples with actin polymerization and cell-matrix adhesion to regulate cell protrusions and retract trailing edges of migrating cells. Although many cells migrate in collective groups during tissue morphogenesis, mechanisms that coordinate actomyosin dynamics in collective cell migration are poorly understood. Migration of Drosophila border cells, a genetically tractable model for collective cell migration, requires nonmuscle myosin-II (Myo-II). How… CONTINUE READING
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