Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp.

@article{Prasad2011PapuamidesEA,
  title={Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp.},
  author={Pritesh Prasad and William Aalbersberg and Klaus-D Feussner and Ryan M. van Wagoner},
  journal={Tetrahedron},
  year={2011},
  volume={67 44},
  pages={8529-8531}
}
Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 μg/mL.