Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/activator protein-1 signaling pathway.

@article{Behren2005PapillomavirusEP,
  title={Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/activator protein-1 signaling pathway.},
  author={Andreas Behren and Christian Simon and Roxana Michaela Schwab and Ekaterina Loetzsch and Stephan Brodbeck and Evamaria Huber and Frank Stubenrauch and Hans Peter Zenner and Thomas Iftner},
  journal={Cancer research},
  year={2005},
  volume={65 24},
  pages={11613-21}
}
Papillomaviruses are involved in the development of cancers of the female cervix, head and neck, and skin. An excellent model to study papillomavirus-induced tumor induction and progression is the New Zealand White rabbit, where the skin is infected with the cottontail rabbit papillomavirus (CRPV). This leads to the formation of benign tumors that progress into invasive and metastasizing carcinomas without the need for cofactors. We have shown previously that specific mutations in the… CONTINUE READING
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Identification of the E9^E2C cDNA and functional characterization of the gene product reveal a new repressor of transcription and replication in cottontail rabbit papillomavirus

  • S Jeckel, E Lötzsch, E Huber, F Stubenrauch, T. Iftner
  • J Virol 2003;77:8736–44
  • 2003
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