Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.

@article{Wells2000PapillomavirusEI,
  title={Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.},
  author={Susanne I Wells and Delicia A. Francis and Alla Y. Karpova and J. J. Dowhanick and John D. Benson and Peter M Howley},
  journal={The EMBO journal},
  year={2000},
  volume={19 21},
  pages={5762-71}
}
A hallmark of human papillomavirus (HPV) associated carcinogenesis is the integration of the viral DNA into the cellular genome, usually accompanied by the loss of expression of the viral E2 gene. E2 binds to and represses the viral promoter directing expression of the E6 and E7 oncogenes. The re-introduction and expression of exogenous E2 in HPV-positive cancer cells results in cellular growth arrest, while growth in the context of exogenous E2 can be restored through the expression of… CONTINUE READING

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