Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate

  title={Papillary thyroid carcinoma shows elevated levels of 2-hydroxyglutarate},
  author={Dinesh Rakheja and Richard L. Boriack and Midori Mitui and Shama Khan Khokhar and Shelby A. Holt and Payal Kapur},
  journal={Tumor Biology},
Elevated levels of d-2-hydroxyglutarate (d-2-HG) occur in gliomas and myeloid leukemias associated with mutations of IDH1 and IDH2. l-2-Hydroxyglutaric aciduria, an inherited metabolic disorder, predisposes to brain tumors. Therefore, we asked whether sporadic cancers, without IDH1 or IDH2 hot-spot mutations, show elevated 2-hydroxyglutarate levels. We retrieved 15 pairs of frozen papillary thyroid carcinoma (PTC) and adjacent non-neoplastic thyroid, and 14 pairs of hyperplastic nodule (HN) and… CONTINUE READING


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