Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation.

@article{Stremnitzer2015PapainDT,
  title={Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation.},
  author={Caroline Stremnitzer and Krisztina Manzano-Szalai and Anna Willensdorfer and Philipp M. Starkl and Mario Pieper and Peter K{\"o}nig and Michael Mildner and Erwin Tschachler and Ursula Reichart and Erika Jensen-Jarolim},
  journal={The Journal of investigative dermatology},
  year={2015},
  volume={135 7},
  pages={1790-1800}
}
Papain is commonly used in food, pharmaceutical, textile, and cosmetic industries and is known to induce occupational allergic asthma. We have previously shown that the papain-like cysteine protease Dermatophagoides pteronyssinus 1 from house dust mite exhibits percutaneous sensitization potential. We aimed here to investigate the potential of papain itself… CONTINUE READING