Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation.

  title={Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation.},
  author={Vyacheslav S. Slyshenkov and Mariola Rakowska and A. G. Moiseenok and Lech Wojtczak},
  journal={Free radical biology \& medicine},
  volume={19 6},

Protective effect of pantothenic acid and related compounds against permeabilization of Ehrlich ascites tumour cells by digitonin.

It is proposed that increased resistance to the damaging effect of submillimolar concentrations of digitonin is due to the increased rate of cholesterol biosynthesis, and incorporation of [14C]acetate into cholesterol is increased in the cells preincubated with pantothenic acid.

Pantothenate prevents disturbances in the synaptosomal glutathione system and functional state of synaptosomal membrane under oxidative stress conditions

The results provide evidence for the regulatory effect of the glutathione redox status on the structural and functional state of synaptosomal membranes, and for its possible modulation by the CoA biosynthetic precursor.

Protective role of L-methionine against free radical damage of rat brain synaptosomes.

Preincubation of the synaptosomal/mitochondrial fraction with 0.5 or 1.0 mM L-methionine significantly protected against lipid peroxidation, membrane damage and changes in the glutathione system produced by low (1 mM) concentrations of tert-butylhydroperoxide and completely prevented inactivation of ouabain-sensitive ATPase, glutathionine reductase and glutATHione transferase by such treatment.

Glycerophosphoglycerol, Beta-Alanine, and Pantothenic Acid as Metabolic Companions of Glycolytic Activity and Cell Migration in Breast Cancer Cell Lines

In cancer research, cell lines are used to explore the molecular basis of the disease as a substitute to tissue biopsies. Breast cancer in particular is a very heterogeneous type of cancer, and

Severe pantothenic acid deficiency induces alterations in the intestinal mucosal proteome of starter Pekin ducks

PAD leads to growth depression and intestinal hypofunction of ducks, which are associated with impaired energy generation, abnormal intestinal absorption, and regulation of actin cytoskeleton processes.

Protection by pantothenol and beta-carotene against liver damage produced by low-dose gamma radiation.

It is concluded that pantothenol is an excellent radioprotective agent against low-dose gamma radiation in rats exposed to a total dose of 0.75 Gy of gamma radiation from a 60Co source.

Coenzyme A protects very-low-density lipoproteins against peroxidation and increases plasma triacylglycerol metabolism.

  • A. Conte
  • Biology
    International journal of tissue reactions
  • 1992
This study shows that CoA protects VLDL from peroxidation in a significant and concentration-dependent manner and increases plasma triacylglycerol metabolism.

Phospholipase A2 dependent release of fatty acids from peroxidized membranes.

  • A. SevanianE. Kim
  • Chemistry, Biology
    Journal of free radicals in biology & medicine
  • 1985

Microsomal lipid peroxidation.

Effect of glucagon and phorbol myristate acetate on oxidative demethylation and lipid peroxidation in isolated hepatocytes.

Oxidative demethylation of aminopyrine and peroxidation of endogenous lipids induced by cumene hydroperoxide and consequences of the phosphorylation of various isoforms of cytochrome P-450 for metabolic functions of the monooxygenase system are discussed.

The leakage and destruction of CoA in isolated mitochondria.

Lysosomal contamination thus probably explains most of the breakdown of CoA in experiments with isolated mitochondria and can be reversed by ATP, evidently by a rephosphorylation system present in mitochondrial preparations.

Protection by pantethine, pantothenic acid and cystamine against carbon tetrachloride-induced hepatotoxicity in the rat.

The daily ip administration of pantethine, pantothenic acid or cystamine for 5 days conferred significant protection against the hepatotoxic and peroxidative actions of a 0.5 mL/kg ip dose of CCl4 in rats.

Role of pantothenic and ascorbic acid in wound healing processes: in vitro study on fibroblasts.

  • B. LacroixE. DidierJ. Grenier
  • Medicine, Biology
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
  • 1988
The results suggest that the combined use of these two vitamins might be of interest in postsurgical therapy and in wound healing.