Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis.

Abstract

OBJECTIVES To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1) erosive oesophagitis. METHODS Patients (371) were randomly assigned to receive pantoprazole 10, 20 or 40 mg or ranitidine 150 mg. Endoscopies were performed after 1, 3, 6 and 12 months or when symptoms suggesting relapse (grade = 2) developed. Gastric biopsies were obtained at baseline and on at least one postbaseline visit. Symptom-free days and Gelusil use were assessed. RESULTS Pantoprazole was significantly (P < 0.001) more effective in maintaining erosive oesophagitis healing. After 12 months, 33%, 40%, 68% and 82% of patients remained healed for the ranitidine and pantoprazole 10, 20 and 40 mg groups, respectively. Daytime and night-time heartburn were eliminated in > 90% of days for the pantoprazole 40 mg group. Gelusil use was significantly lower with pantoprazole 20 and 40 mg than with ranitidine (P < 0.02) during the first 9 months. CONCLUSIONS Twelve months of maintenance therapy with pantoprazole (10-40 mg once daily) was superior to ranitidine (150 mg twice daily) in maintaining erosive oesophagitis healing. Pantoprazole 40 mg provided the most consistent efficacy and was well tolerated.

Statistics

0100200'04'05'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

309 Citations

Semantic Scholar estimates that this publication has 309 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Metz2003PantoprazoleMT, title={Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis.}, author={David Metz and W. J. Bochenek}, journal={Alimentary pharmacology & therapeutics}, year={2003}, volume={17 1}, pages={155-64} }