Panoramix enforces piRNA-dependent cotranscriptional silencing

  title={Panoramix enforces piRNA-dependent cotranscriptional silencing},
  author={Yang Yu and Jiaqi Gu and Ying Jin and Yicheng Luo and Jonathan B. Preall and Jinbiao Ma and Benjamin Czech and Gregory J Hannon},
The Piwi-interacting RNA (piRNA) pathway is a small RNA–based innate immune system that defends germ cell genomes against transposons. In Drosophila ovaries, the nuclear Piwi protein is required for transcriptional silencing of transposons, though the precise mechanisms by which this occurs are unknown. Here we show that the CG9754 protein is a component of Piwi complexes that functions downstream of Piwi and its binding partner, Asterix, in transcriptional silencing. Enforced tethering of… CONTINUE READING
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