Panorama of ancient metazoan macromolecular complexes

  title={Panorama of ancient metazoan macromolecular complexes},
  author={Cuihong Wan and Blake Borgeson and Sadhna Phanse and Fan Tu and Kevin Drew and Greg W. Clark and Xuejian Xiong and Olga Kagan and Julian H M Kwan and Alexandr Berzginov and Kyle Chessman and Swati Pal and Graham L. Cromar and Ophelia Papoulas and Zuyao Ni and Daniel R. Boutz and Snejana Stoilova and Pierre Claver Havugimana and Xinghua Guo and Ramy Habashy Malty and Mihail Sarov and Jack Greenblatt and Mohan Babu and Brent Derry and Elisabeth R. M. Tillier and John B. Wallingford and John Parkinson and Edward M. Marcotte and Andrew Emili},
Macromolecular complexes are essential to conserved biological processes, but their prevalence across animals is unclear. By combining extensive biochemical fractionation with quantitative mass spectrometry, here we directly examined the composition of soluble multiprotein complexes among diverse metazoan models. Using an integrative approach, we generated a draft conservation map consisting of more than one million putative high-confidence co-complex interactions for species with fully… CONTINUE READING
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Preparing the next generation of molecular biologists

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