Panning for gold: genome-wide scanning for linkage in type 1 diabetes.

  title={Panning for gold: genome-wide scanning for linkage in type 1 diabetes.},
  author={John A. Todd and Martin Farrall},
  journal={Human molecular genetics},
  volume={5 Spec No},
Genome-wide scans for linkage of chromosome regions to type 1 diabetes in affected sib pair families have revealed that the major susceptibility locus resides within the major histocompatibility complex (MHC) on chromosome 6p21 (lambda S = 2.4). It is recognized that the MHC contains multiple susceptibility loci (referred to collectively as IDDM1), including the class II antigen receptor genes, which control the major pathological feature of the disease: T-lymphocyte-mediated autoimmune… CONTINUE READING
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