Panniculitis in patients treated with BRAF inhibitors: a case series.

  title={Panniculitis in patients treated with BRAF inhibitors: a case series.},
  author={Bonita Choy and Shaun Chou and Rachael M Anforth and Pablo Fern{\'a}ndez-Pe{\~n}as},
  journal={The American Journal of dermatopathology},
  volume={36 6},
Panniculitis is a rare complication of BRAF inhibitor therapy that is used to treat patients with BRAF-mutated metastatic melanoma. We present a clinicopathologic review of 9 patients who developed panniculitis while on BRAF inhibitor therapy. In 13% of patients on vemurafenib, 3% of patients on dabrafenib and 10% on combination of dabrafenib + trametinib, tender erythematous nodular lesions of panniculitis appeared on legs, arms and trunk. Histological evaluation of 8 biopsies from 7 patients… CONTINUE READING