Pannexins and gap junction protein diversity

  title={Pannexins and gap junction protein diversity},
  author={Valery I Shestopalov and Yury V Panchin},
  journal={Cellular and Molecular Life Sciences},
Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ formation. Another family of GJ proteins (innexins) were first found in invertebrates and were proposed to be renamed pannexins after their orthologs were discovered in vertebrates. The lack of both connexins and pannexins in the genomes of some metazoans suggests that other, still undiscovered GJ proteins exist… CONTINUE READING