Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.

@article{Ambrosi2010Pannexin1AP,
  title={Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.},
  author={Cinzia Ambrosi and Oliver Gassmann and Jennifer N Pranskevich and Daniela Boassa and Amy E Smock and Jun-jie Wang and Gerhard Dahl and Claudia Steinem and Gina E. Sosinsky},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 32},
  pages={24420-31}
}
Pannexins are homologous to innexins, the invertebrate gap junction family. However, mammalian pannexin1 does not form canonical gap junctions, instead forming hexameric oligomers in single plasma membranes and intracellularly. Pannexin1 acts as an ATP release channel, whereas less is known about the function of Pannexin2. We purified cellular membranes isolated from MDCK cells stably expressing rat Pannexin1 or Pannexin2 and identified pannexin channels (pannexons) in single membranes by… CONTINUE READING
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