Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc

@inproceedings{Brough2009Pannexin1dependentCA,
  title={Pannexin-1-dependent caspase-1 activation and secretion of IL-1β is regulated by zinc},
  author={David Brough and Pablo Pelegr{\'i}n and Nancy J. Rothwell},
  booktitle={European journal of immunology},
  year={2009}
}
Inflammatory processes induced by IL-1beta are critical for host defence responses, but are also implicated in disease. Zinc deficiency is a common consequence of, or contributor to, human inflammatory disease. However, the molecular mechanisms through which zinc contributes to inflammatory disease remain largely unknown. We report here that zinc metabolism regulates caspase-1 activation and IL-1beta secretion. One of the endogenous mediators of IL-1beta secretion is adenosine triphosphate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Similar Papers

Loading similar papers…