Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region.

@article{Sandilos2012Pannexin1A,
  title={Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region.},
  author={Joanna K. Sandilos and Y. L. Chiu and Faraaz B. Chekeni and Allison J. Armstrong and Scott F. Walk and Kodi Ravichandran and Douglas A Bayliss},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 14},
  pages={11303-11}
}
Pannexin 1 (PANX1) channels mediate release of ATP, a "find-me" signal that recruits macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated cleavage of PANX1 at its C terminus, but how the C terminus inhibits basal channel activity is not understood. Here, we provide evidence suggesting that the C terminus interacts with the human PANX1 (hPANX1) pore and that cleavage-mediated channel activation requires disruption of this inhibitory interaction. Basally… CONTINUE READING

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