Panipenem, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats.

@article{Yamamura1999PanipenemAC,
  title={Panipenem, a carbapenem antibiotic, enhances the glucuronidation of intravenously administered valproic acid in rats.},
  author={Naotoshi Yamamura and K. Imura and Hideo Naganuma and Kazuhiko Nishimura},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 6},
  pages={724-30}
}
Previously, a significant decrease in the trough plasma-concentration of valproic acid (VPA) owing to the concomitant administration of panipenem (PAPM)/betamipron, a carbapenem antibiotic, in epileptic patients was reported. To determine the site and mechanism of the drug interaction between VPA and PAPM, we performed in vivo and in vitro experiments using rats. A 30 mg/kg bolus dose of VPA was given i.v. to normal Sprague-Dawley rats, nephrectomized rats, and hepatectomized rats, with and… CONTINUE READING

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