Panic Disorder and Response to Sertraline: The Effect of Previous Treatment with Benzodiazepines

@article{Rapaport2001PanicDA,
  title={Panic Disorder and Response to Sertraline: The Effect of Previous Treatment with Benzodiazepines},
  author={Mark Hyman Rapaport and Mark H. Pollack and Cathryn M. Clary and Jack Mardekian and Robert Wolkow},
  journal={Journal of Clinical Psychopharmacology},
  year={2001},
  volume={21},
  pages={104-107}
}
More than 50% of patients who seek psychiatric care for panic disorder have previously received prescriptions for a benzodiazepine (BZ). Research on the treatment of generalized anxiety suggests that a history of BZ exposure might decrease the efficacy and tolerability of treatment with a serotonergic anxiolytic. This study examines the effect of prior BZ treatment on the efficacy and tolerability of sertraline treatment for panic disorder. Data were pooled (N = 705) from four double-blind… 
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