Paneth cell α-defensins and enteric microbiota in health and disease

  title={Paneth cell α-defensins and enteric microbiota in health and disease},
  author={Kiminori Nakamura and Naoya Sakuragi and Akiko TAKAKUWA and Tokiyoshi Ayabe},
  booktitle={Bioscience of microbiota, food and health},
Antimicrobial peptides are major effectors of innate immunity of multicellular organisms including humans and play a critical role in host defense, and their importance is widely recognized. The epithelium of the intestine is the largest surface area exposed to the outer environment, including pathogens, toxins and foods. The Paneth cell lineage of intestinal epithelial cells produces and secretes α-defensin antimicrobial peptides and functions in innate enteric immunity by removing pathogens… CONTINUE READING
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