Paneth cell–derived growth factors support tumorigenesis in the small intestine

  title={Paneth cell–derived growth factors support tumorigenesis in the small intestine},
  author={Qing Chen and Kohei Suzuki and Luis F Sifuentes-Dominguez and Naoteru Miyata and Jie Song and Adam M. Lopez and Petro Starokadomskyy and Purva Gopal and Igor Dozmorov and Shuai Tan and BuJun Ge and Ezra Burstein},
  journal={Life Science Alliance},
Paneth cells, known for their production of antimicrobial peptides and growth factors in the gut epithelium, are found to play a key role in intestinal tumor formation through secretion of Wnt3. Paneth cells (PCs) are small intestinal epithelial cells that secrete antimicrobial peptides and growth factors, such as Wnt ligands. Intriguingly, the context in which PC-derived Wnt secretion is relevant in vivo remains unknown as intestinal epithelial ablation of Wnt does not affect homeostatic… 
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  • S. Koch
  • Biology
    Differentiation; research in biological diversity
  • 2017
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