Pandemrix vaccine: why was the public not told of early warning signs?

  title={Pandemrix vaccine: why was the public not told of early warning signs?},
  author={Peter Doshi},
  journal={British Medical Journal},
  • P. Doshi
  • Published 20 September 2018
  • Medicine
  • British Medical Journal
Eight years after the pandemic influenza outbreak, a lawsuit alleging that GlaxoSmithKline’s Pandemrix vaccine caused narcolepsy has unearthed internal reports suggesting problems with the vaccine’s safety. Peter Doshi asks what this means for the future of transparency during public health emergencies 
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We are writing to respond to The BMJ ’s feature article about the Pandemrix vaccine.”1 Our response focuses on some of the statements in the article as well the methodology on which the major premise
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The Health Service Executive (HSE) decided to purchase Pandemrix and continued to distribute it even after they knew it was dangerous and untested, and before most of the public in Ireland received it.
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The increased risk of narcolepsy after vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine indicates a causal association, consistent with findings from Finland.
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Pandemrix vaccine contributed to the onset of narcolepsy among those 4 to 19 years old during the pandemic influenza in 2009–2010 in Finland and the role of the adjuvant in particular warrants further research.
Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland
A sudden increase in the incidence of abrupt childhood narcolepsy was observed in Finland in 2010 and it is likely that Pandemrix vaccination contributed, perhaps together with other environmental factors, to this increase in genetically susceptible children.
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