Pandemrix vaccine: why was the public not told of early warning signs?

  title={Pandemrix vaccine: why was the public not told of early warning signs?},
  author={Peter Doshi},
  journal={British Medical Journal},
  • P. Doshi
  • Published 20 September 2018
  • Medicine
  • British Medical Journal
Eight years after the pandemic influenza outbreak, a lawsuit alleging that GlaxoSmithKline’s Pandemrix vaccine caused narcolepsy has unearthed internal reports suggesting problems with the vaccine’s safety. Peter Doshi asks what this means for the future of transparency during public health emergencies 
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  • Medicine, Political Science
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  • 2018
BMJ Associate Editor, Peter Doshi, noted that emerging information from one of the European lawsuits – alleging that Pandemrix was associated with cases of narcolepsy – have indicated that GSK and public health officials were aware of cases of other serious AEs, but that the general public was not informed about the potential implications.
Thomas Breuer and colleagues at GlaxoSmithKline respond to Peter Doshi
We are writing to respond to The BMJ ’s feature article about the Pandemrix vaccine.”1 Our response focuses on some of the statements in the article as well the methodology on which the major premise
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  • 2020
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This point-of-view aims at providing a narrative review of epidemiological issues, clinical data, and pathogenetic hypotheses of thrombosis linked to both COVID-19 and its vaccines, helping medical practitioners to offer up-to-date and evidence-based counseling to their often-alarmed patients with acute or chronic cardiovascularThrombotic events.
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Irish MP calls for key documents on Pandemrix to be handed to lawyers representing children with narcolepsy
  • C. Dyer
  • History
    British Medical Journal
  • 2017
The Health Service Executive (HSE) decided to purchase Pandemrix and continued to distribute it even after they knew it was dangerous and untested, and before most of the public in Ireland received it.
Only 12% of Germans say they will have H1N1 vaccine after row blows up over safety of adjuvants
A president of the German College of General Practitioners and Family Physicians has told the BMJ that Pandemrix has not been sufficiently tested to be declared safe for millions of people, especially small children and pregnant women.
Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis
The increased risk of narcolepsy after vaccination with ASO3 adjuvanted pandemic A/H1N1 2009 vaccine indicates a causal association, consistent with findings from Finland.
Pharmacovigilance: paradise lost, regained or postponed? The William Withering Lecture 1994.
  • M. Rawlins
  • Medicine
    Journal of the Royal College of Physicians of London
  • 1995
La pharmacovigilance consiste a verifier et s'assurer de la securite des medicaments mis sur le marche, en verifiant ses effets chez l'homme, et en developpant des strategies pour minimiser les
AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland
Pandemrix vaccine contributed to the onset of narcolepsy among those 4 to 19 years old during the pandemic influenza in 2009–2010 in Finland and the role of the adjuvant in particular warrants further research.
Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland
A sudden increase in the incidence of abrupt childhood narcolepsy was observed in Finland in 2010 and it is likely that Pandemrix vaccination contributed, perhaps together with other environmental factors, to this increase in genetically susceptible children.
European Centre for Disease Prevention and Control.
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  • Medicine, Business
    Nursing standard (Royal College of Nursing (Great Britain) : 1987)
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The European Centre for Disease Prevention and Control was set up in 2005 to strengthen Europe's defences against infectious diseases. The centre is an independent agency of the European Union and is