Pandemic threat posed by avian influenza A viruses.

  title={Pandemic threat posed by avian influenza A viruses.},
  author={Taisuke Horimoto and Yoshihiro Kawaoka},
  journal={Clinical microbiology reviews},
  volume={14 1},
Influenza pandemics, defined as global outbreaks of the disease due to viruses with new antigenic subtypes, have exacted high death tolls from human populations. The last two pandemics were caused by hybrid viruses, or reassortants, that harbored a combination of avian and human viral genes. Avian influenza viruses are therefore key contributors to the… CONTINUE READING